Cannabinoids naturally occur in the human body, in the nervous and immune systems. There are 3 types of cannabinoids:
- Synthetic Cannabinoids that are produced in a laboratory (ex: pharmaceutical medications)
- Endogenous Cannabinoids which are produced in the human body (may be referred to as endocannabinoid system)
- The Endocannabinoid System (ECS) is a nerve cell signaling system (communication between cells) in the body that helps regulate and balance bodily functions, maintaining physiological, cognitive and emotional balance
- Receptors CB1 & CB2 are located in the body. CB1 receptors are mainly located in the brain and central nervous system. CB2 receptors are mostly located in the organs.
- There are 2 endocannabinoids: anandamide (AEA) and 2-arachidonoylglyerol (2-AG)
- Phytocannabinoids which are produced in the cannabis plant. Examples are THC and CBD (referred to as cannabinoids)
- Cannabinoids bind to endocannabinoid receptors in the body. These receptors are found throughout the body.
- By stimulating the Endocannabinoid system with Phytocannabinoids will restore balance and relieve symptoms
|CB1 Receptors||CB2 Receptors|
|Location||Brain & Spinal cord Some Peripheral tissue||Immune tissue|
|Regulates||Appetite Movement Posture Sensory perception Memory Cognition Emotion||Inflammation & Pain (regulation of cytokine release from immune cells and immune cell migration)|
CB2 receptors do not cause the high that stimulating the CB1 receptors may cause.